DSSR-derived G-quadruplex features in PDB entry 2may
- Structure of a G-quadruplex containing a single lna modification
- Li, Z., Lech, C., Adrian, M., Heddi, B., Phan, A.T.: "Engineering G4: Towards effective incorporation of locked nucleic acid into G-quadruplexes." To be published
- G4 notes
- 3 G-tetrads, 1 G4 helix, 1 G4 stem · 3(-P-Lw-Ln), hybrid-1(3+1), UUDU
1 glyco-bond=ss-s groove=-wn- planarity=0.171 type=other nts=4 GGGG A.DG3,A.DG9,A.DG17,A.DG21 2 glyco-bond=--s- groove=-wn- planarity=0.176 type=other nts=4 gGGG A.LCG4,A.DG10,A.DG16,A.DG22 3 glyco-bond=--s- groove=-wn- planarity=0.207 type=bowl nts=4 GGGG A.DG5,A.DG11,A.DG15,A.DG23
In DSSR, a G4-helix is defined by stacking interactions of G-tetrads, regardless of backbone connectivity, and may contain more than one G4-stem.
Helix#1, 3 G-tetrad layers, INTRA-molecular, with 1 stem
In DSSR, a G4-stem is defined as a G4-helix with backbone connectivity. Bulges are also allowed along each of the four strands.