DSSR-derived G-quadruplex features in PDB entry 4p1d
- X-ray (1.55 Å)
- Structure of the complex of a bimolecular human telomeric DNA with coptisine
- Ferraroni, M., Bazzicalupi, C., Gratteri, P., Bilia, A.R., Sissi, C.: "Crystal Structure of the complex of a bimolecular human telomeric DNA with Coptisine." To be published
- G4 notes
- 3 G-tetrads, 1 G4 helix, 1 G4 stem · parallel(4+0), UUUU
1 glyco-bond=---- groove=---- planarity=0.138 type=planar nts=4 GGGG A.DG3,A.DG9,B.DG15,B.DG21 2 glyco-bond=---- groove=---- planarity=0.136 type=planar nts=4 GGGG A.DG4,A.DG10,B.DG16,B.DG22 3 glyco-bond=---- groove=---- planarity=0.264 type=bowl nts=4 GGGG A.DG5,A.DG11,B.DG17,B.DG23
In DSSR, a G4-helix is defined by stacking interactions of G-tetrads, regardless of backbone connectivity, and may contain more than one G4-stem.
Helix#1, 3 G-tetrad layers, inter-molecular, with 1 stem
In DSSR, a G4-stem is defined as a G4-helix with backbone connectivity. Bulges are also allowed along each of the four strands.