DSSR-derived G-quadruplex features in PDB entry 6jwd
Poster "DSSR-Enabled Automatic Identification and Annotation of G-quadruplexes in the PDB" presented at the RNA2020 online meeting
Citation: before a paper dedicated to the DSSR-G4 module comes out, please cite the 2015 DSSR paper published in Nucleic Acids Research.
- Structure of ret G-quadruplex in complex with berberine
- Wang, F., Wang, C., Liu, Y., Lan, W., Han, H., Wang, R., Huang, S., Cao, C.: (2020) "Colchicine selective interaction with oncogene RET G-quadruplex revealed by NMR." Chem.Commun.(Camb.), 56, 2099-2102.
- G-quadruplexes (G4s) are frequently formed in the promoter regions of oncogenes, considered as promising drug targets for anticancer therapy. Due to high structure similarity of G4s, discovering ligands selectively interacting with only one G4 is extremely difficult. Here, mainly by NMR, we report that colchicine selectively binds to oncogene RET G4-DNA.
- G4 notes
- 3 G-tetrads, 1 G4 helix, 1 G4 stem · 3(-P-P-P), parallel(4+0), UUUU
1 glyco-bond=ssss groove=---- planarity=0.114 type=planar nts=4 GGGG A.DG1,A.DG7,A.DG11,A.DG17 2 glyco-bond=---- groove=---- planarity=0.100 type=planar nts=4 GGGG A.DG2,A.DG8,A.DG12,A.DG18 3 glyco-bond=---- groove=---- planarity=0.144 type=planar nts=4 GGGG A.DG3,A.DG9,A.DG13,A.DG19