DSSR-derived G-quadruplex features in PDB entry 6jwe
Poster "DSSR-Enabled Automatic Identification and Annotation of G-quadruplexes in the PDB" presented at the RNA2020 online meeting
Citation: before a paper dedicated to the DSSR-G4 module comes out, please cite the 2015 DSSR paper published in Nucleic Acids Research.
- Structure of ret G-quadruplex in complex with colchicine
- Wang, F., Wang, C., Liu, Y., Lan, W., Han, H., Wang, R., Huang, S., Cao, C.: (2020) "Colchicine selective interaction with oncogene RET G-quadruplex revealed by NMR." Chem.Commun.(Camb.), 56, 2099-2102.
- G-quadruplexes (G4s) are frequently formed in the promoter regions of oncogenes, considered as promising drug targets for anticancer therapy. Due to high structure similarity of G4s, discovering ligands selectively interacting with only one G4 is extremely difficult. Here, mainly by NMR, we report that colchicine selectively binds to oncogene RET G4-DNA.
- G4 notes
- 3 G-tetrads, 1 G4 helix, 1 G4 stem · 3(-P-P-P), parallel(4+0), UUUU
1 glyco-bond=ssss groove=---- planarity=0.086 type=planar nts=4 GGGG A.DG1,A.DG7,A.DG11,A.DG17 2 glyco-bond=---- groove=---- planarity=0.063 type=planar nts=4 GGGG A.DG2,A.DG8,A.DG12,A.DG18 3 glyco-bond=---- groove=---- planarity=0.122 type=planar nts=4 GGGG A.DG3,A.DG9,A.DG13,A.DG19