Summary information [schematics · tetrads · helices · stems · costacks · homepage]

PDB-id
6t2g
Class
DNA
Method
NMR
Summary
NMR structure of kras32r g25t conformer G-quadruplex within kras promoter region
Reference
Marquevielle, J., Robert, C., Lagrabette, O., Wahid, M., Bourdoncle, A., Xodo, L., Mergny, J.L., Salgado, G.: "Structure of Multiple G-quadruplexes in equilibrium in KRAS promoter region." To be published
Abstract
 
G4 notes
2 G-tetrads

Base-block schematics in six views [summary · tetrads · helices · stems · costacks · homepage]

PyMOL session file PDB file View in 3Dmol.js

List of 2 G-tetrads [summary · schematics · helices · stems · costacks · homepage]

 1 glyco-bond=---- groove=---- planarity=0.448 type=bowl   nts=4 GGGG A.DG2,A.DG6,A.DG11,A.DG26
 2 glyco-bond=---- groove=---- planarity=0.655 type=saddle nts=4 GGGG A.DG4,A.DG9,A.DG13,A.DG28

List of 0 G4-helices [summary · schematics · tetrads · stems · costacks · homepage]

In DSSR, a G4-helix is defined by stacking interactions of G-tetrads, regardless of backbone connectivity, and may contain more than one G4-stem.

List of 0 G4-stems [summary · schematics · tetrads · helices · costacks · homepage]

In DSSR, a G4-stem is defined as a G4-helix with backbone connectivity. Bulges are also allowed along each of the four strands.

List of 0 G4 coaxial stacks [summary · schematics · tetrads · helices · stems · homepage]

List of 6 non-stem G4-loops (including the two closing Gs)

 1 type=lateral   helix=#-1 nts=5 GGGCG A.DG2,A.DG3,A.DG4,A.DC5,A.DG6
 2 type=lateral   helix=#-2 nts=6 GCGGTG A.DG4,A.DC5,A.DG6,A.DG7,A.DT8,A.DG9
 3 type=lateral   helix=#-1 nts=6 GGTGTG A.DG6,A.DG7,A.DT8,A.DG9,A.DT10,A.DG11
 4 type=lateral   helix=#-2 nts=5 GTGGG A.DG9,A.DT10,A.DG11,A.DG12,A.DG13
 5 type=lateral   helix=#-1 nts=16 GGGAAGAGGGAAGATG A.DG11,A.DG12,A.DG13,A.DA14,A.DA15,A.DG16,A.DA17,A.DG18,A.DG19,A.DG20,A.DA21,A.DA22,A.DG23,A.DA24,A.DT25,A.DG26
 6 type=lateral   helix=#-2 nts=16 GAAGAGGGAAGATGGG A.DG13,A.DA14,A.DA15,A.DG16,A.DA17,A.DG18,A.DG19,A.DG20,A.DA21,A.DA22,A.DG23,A.DA24,A.DT25,A.DG26,A.DG27,A.DG28